WebThe causes of hypersalivation, a distressing side effect that occurs in 31%–54% of patients receiving clozapine therapy, are nonspecific. [ 1] It may be mediated by the imbalance between M3 receptor blockade (decrease in salivation) and M4 receptor stimulation (increase in salivary output). Another explanation is that clozapine interferes ... WebAug 15, 2009 · Article AbstractObjective: Clozapine-induced hypersalivation (CIH) occurs in up to 57% of treated patients and can be the source of considerable subjective distress. Previous open-label studies suggest that sublingual ipratropium bromide may be effective in treating CIH.Method: We conducted a randomized, double-blind, placebo-controlled …
Clozapine Induced Hypersalivation (Sialorrhoea)
WebTreatment augmentation with drugs such as aripiprazole may help to reduce the required clozapine dose. This can reduce sedation, but should not be prescribed without consultation with a psychiatrist. 12. Hypersalivation . Hypersalivation, particularly while sleeping, is a troublesome adverse effect that may embarrass and stigmatise patients. WebClozapine is the optimal drug for patients with treatment-resistant schizophrenia. Previous reports demonstrated that relative to other antipsychotics, clozapine exerts a superior therapeutic effect and a lower incidence of extrapyramidal disorder that is a typical adverse effect of antipsychotics [ 3 , 4 ]. crypto trading books for beginners
The severe complication of Stevens–Johnson syndrome induced …
WebOct 1, 2011 · Pharmacologic treatments. Pharmacologic interventions rely on counteracting clozapine’s secretion-inducing effects by opposing M4 agonism, α2 antagonism, or both. Antimuscarinic medications such as benztropine, trihexyphenidyl, amitriptyline, or pirenzepine often are used to reduce hypersalivation, 6 although 1 systematic review … WebThe severe complication of Stevens–Johnson syndrome induced by long-term clozapine treatment in a male schizophrenia patient: a case report Ming-Kung Wu,1 Weilun Chung,2 Ching-Kuan Wu,2 Ping-Tao Tseng2 1Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Department of Psychiatry, … WebHypersalivation is reported to affect approximately 30% of patients treated with clozapine. 22 Excessive saliva production is often more prominent at night and generally occurs shortly after clozapine is initiated. 22 The exact mechanism of clozapine-induced hypersalivation is not known. 22 Chewing sugarless gum is often recommended, but … crypto trading blogs