WebMay 14, 2012 · Fbw7α is a subunit of the E3 ubiquitin ligase complex SCF Fbw7 that recognizes c-Myc in response to specific stimuli leading to ubiquitination and subsequent proteasome degradation of c-Myc . In contrast, USP-28, which forms a complex with Fbw7α and counteracts the degradation of c-Myc by removing ubiquitins conjugated by Fbw7α ( … WebApr 6, 2024 · The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal …
FBW7 Mediates Senescence and Pulmonary Fibrosis …
WebFeb 27, 2024 · Fbw7α through its WD domain interacts with Runx2 both in a heterologous (HEK293T cells) system as well as osteoblasts. GSK3β was also present in the same complex as determined by co ... WebJul 24, 2024 · Fbw7α-dependent c-Jun ubiquitylation reactions were carried out in vitro with radiolabeled c-Jun, Fbw7α alone, or Fbw7α in the presence of equal amounts of non-labeled in vitro transcribed and translated BLM (WT) or BLM mutants (Q645X, Q672R, and C1055S). The ubiquitylated products were detected by autoradiography. hdfc bank loan statement kaise nikale
BLM Potentiates c-Jun Degradation and Alters Its Function as an ...
WebAug 1, 2024 · In this study, we identified USP38 as a DUB that positively controls c-Myc expression. USP38 is able to enhance the stability of c-Myc by antagonizing the function of FBW7α. Importantly, USP38 regulates cell proliferation through c-Myc. Thus, USP38 plays an important role in the regulation of c-Myc function. WebOct 26, 2004 · This was further demonstrated by fusion of the Fbw7α-specific exon to full-length Fbw7γ, which redistributed Fbw7γ from a nucleolar to a nucleoplasmic pattern (panel N-α +Fbw7γ in Figure 1E). Although we found that BD1 functions as the sole Fbw7γ NLS, none of the basic regions specifically affected nucleolar targeting ( Figure 1E and data ... WebSep 13, 2016 · FBW7 recognizes a conserved degron surrounding threonine 236 (T236) in SOX9 that is phosphorylated by GSK3 kinase and consequently degraded by SCF FBW7α. Failure to degrade SOX9 … hdfc home loan kukatpally